Fig. 7.

Sustained effect of 2-MPPA on hyperalgesia after cessation of dosing. Once analgesia was achieved after 15 days of dosing, drug administration was stopped. However, withdrawal latency measurements were continued. The analgesic efficacy of 2-MPPA persisted up to 17 days after drug administration was halted. Statistical analyses were conducted with comparisons made to vehicle-treated animals. Significance criteria of P < 0.05 were used and are noted with an asterisk (*).