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Lactate and ATP levels and respiratory chain activities in CYB5R3-defective cells. (A) Lactate production and (B) ATP levels in MRC-5 cells stably transfected with CYB5R3 shRNA and HDFs from patients P1 and P2. (C) Respiratory chain enzymatic activities of complexes I, II, III, and IV relative to citrate synthase. Values are means±SD of three independent experiments. shRNA control versus CYB5R3 shRNA, HDF neo versus P1 and P2. *p<0.05, **p<0.01, ***p<0.001.
