Table 3.

Nonhematologic side effects

Toxicity	Thalidomide, n (%) (N = 44)		Lenalidomide, n (%) (N = 41)		Lenalidomide plus prednisone, n (%) (N = 40)		P
	All grades	Grades 3-4	All grades	Grades 3-4	All grades	Grades 3-4
Thrombosis	1 (2)	1 (2)	2 (5)	1 (2)	2 (5)	2 (5)	.77
Edema	9 (20)	1 (2)	9 (22)	1 (2)	4 (10)	2 (5)	.31
Fatigue	15 (34)	1 (2)	14 (35)	5 (12)	6 (15)	4 (10)	.08
Neuropathy	23 (52)	1 (2)	2 (5)	0	6 (15)	0	.001
Increased liver enzymes	0	0	4 (10)	1 (2)	3 (7)	2 (5)	.12
Rash	16 (36)	1 (2)	7 (18)	3 (7)	15 (37)	0	.07
Bleeding	0	0	0	0	1 (3)	1 (3)	.34