. Author manuscript; available in PMC: 2014 Oct 6.

Published in final edited form as: J Thorac Oncol. 2014 May;9(5):631–638. doi: 10.1097/JTO.0000000000000115

TABLE 2.

ALK IHC vs. ALK FISH for All Readers and Overall after Consensus Review

Reader (n evaluable)	IHC	FISH +	FISH−	Sensitivity (95% CI)	Specificity (95% CI)	Accuracy (95% CI)
Reader 1 (n = 97)	IHC+	39	2	91 (78–96)	96 (88–99)	94 (87–97)
Reader 1 (n = 97)	IHC−	4	52	91 (78–96)	96 (88–99)	94 (87–97)
Reader 2 (n = 99)	IHC+	39	2	89 (76–95)	96 (88–99)	93 (86–97)
Reader 2 (n = 99)	IHC−	5	53	89 (76–95)	96 (88–99)	93 (86–97)
Reader 3 (n = 99)	IHC+	39	2	89 (76–95)	96 (88–99)	93 (86–97)
Reader 3 (n = 99)	IHC−	5	53	89 (76–95)	96 (88–99)	93 (86–97)
Reader 4 (n = 99)	IHC+	42	2^*	93 (82–98)	96^* (88–99)	95^* (89–98)
Reader 4 (n = 99)	IHC−	3	52^*	93 (82–98)	96^* (88–99)	95^* (89–98)
Reader 5 (n = 99)	IHC+	39	2^*	87 (74–94)	96^* (88–99)	92^* (85–96)
Reader 5 (n = 99)	IHC−	6	52^*	87 (74–94)	96^* (88–99)	92^* (85–96)
Reader 6 (n = 99)^*	IHC+	40	2^*	91 (79–96)	96^* (88–99)	94^* (87–97)
Reader 6 (n = 99)^*	IHC−	4	53^*	91 (79–96)	96^* (88–99)	94^* (87–97)
Reader 7 (n = 99)^*	IHC+	40	2^*	91 (79–96)	96^* (88–99)	94^* (87–97)
Reader 7 (n = 99)^*	IHC−	4	53^*	91 (79–96)	96^* (88–99)	94^* (87–97)
Overall (n = 691)^*	IHC+	278	14^*	90 (80–98)	96^* (90–100)	93^* (88–98)
Overall (n = 691)^*	IHC −	31	368^*	90 (80–98)	96^* (90–100)	93^* (88–98)

ALK, anaplastic lymphoma kinase; IHC, immunohistochemistry; FISH, fluoroscence in situ hybridization; CI, confidence interval.

indicates changes from Table 1.