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ALK IHC vs. ALK FISH for Majority Score, Four of Seven Readers in Agreement
| Reader (n evaluable) | IHC | FISH+ | FISH− | Sensitivity (95% CI) | Specificity (95% CI) | Accuracy (95% CI) |
|---|---|---|---|---|---|---|
| Four-reader agreement | IHC+ | 39 | 2 | 91 (78–96) | 96 (88–99) | 94 (87–97) |
| IHC− | 4 | 53 |
ALK, anaplastic lymphoma kinase; IHC, immunohistochemistry; FISH, fluoroscence in situ hybridization; CI, confidence interval.
