Table 1.
Characteristics of the studied samples, taken from different cell lines. Each cell line was grown in several replicas.
| Oncogene | Cell line | Histology | Patient type (source database) | Tissue type | Mutation |
|---|---|---|---|---|---|
| EGFRmut | H3255 | Adeno | Non-smoker; female; Caucasian (Sanger) | Lung | L858R |
| H820 | Adeno | Male; Caucasian (ATCC) | Lymph node | EX19 | |
| H1650 | Adeno | Current-smoker; male; Caucasian (ATCC) | Pleural effusion | EX19 | |
| H1975 | Adeno | Non-smoker; Female (ATCC) | Lung | L858R; T790M | |
| HCC4006 | Adeno | Male; Caucasian (ATCC) | Pleural effusion | EX19 | |
| HCC2279 | Adeno | Unknown (Sanger) | Lung | EX19 | |
| KRASmut | A549 | Adeno | Male; Caucasian (ATCC) | Lung | G12S |
| H2009 | Adeno | Current-smoker; Female; Caucasian (ATCC) | Lymph node | G12A | |
| H460 | Large cell | Male (ATCC) | Pleural effusion | Q61H | |
| NE18 | Squamous | Unknown (Sanger) | Lung | n/aa | |
| EML4-ALK | H2228 | Adeno | Non-smoker; female (ATCC) | Lung | |
| Other oncogenes | H322 | Adeno | Unknown (Sanger) | Lung | |
| (wt to the above) | H1703 | Adeno | Current-smoker; male; Caucasian (ATCC) | Lung | |
| H125 | Adeno | Unknown (Sanger) | Lung | ||
| H1435 | Adeno | Non-smoker; female (ATCC) | Lung | ||
| Calu3 | Adeno | Male; Caucasian (ATCC) | Pleural effusion | ||
| HCC15 | Squamous | Male (Sanger) | Lung | ||
| H520 | Squamous | Male (ATCC) | Lung | ||
| HCC193 | Adeno | Unknown (Sanger) | Lung |
a
KRAS mutation was identified in NE-18 at the University of Colorado Cancer Center through direct sequencing, but the location of the mutation was not recorded.