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. 2014 Aug 22;11(10):3737–3746. doi: 10.1021/mp500497p

Figure 6.

Figure 6

Concentration-dependent flux of [3H]-GlySar (0.01–50 mM total substrate) during jejunal perfusions of wildtype (WT = mPept1+/+) and huPEPT1 (HU = mPept1–/–/hPEPT1+/–) mice. Cin is the inlet concentration of GlySar in perfusate in which Vm′ = 3.75 ± 0.11 nmol/cm2/sec and Km′ = 13.2 ± 1.0 mM for WT mice, r2 = 0.988; Vm′ = 0.50 ± 0.04 nmol/cm2/sec and Km′ = 3.3 ± 0.9 mM for HU mice, r2 = 0.838 (A). Cw is the estimated concentration of GlySar at the membrane wall in which Vm = 3.24 ± 0.13 nmol/cm2/sec and Km = 5.5 ± 0.7 mM for WT mice, r2 = 0.993; Vm = 0.49 ± 0.03 nmol/cm2/sec and Km = 2.7 ± 0.6 mM for HU mice, r2 = 0.973 (B). All studies were performed in pH 6.5 buffer. Data are expressed as mean ± SE (n = 4–6).