Table 5.
Dependence of genotypes and frequencies of RAD51 gene polymorphism alleles on tumor grade in endometrial cancer patients
| Gradea | Endometrial cancer patients | OR (95 % CI)b | p c | |
|---|---|---|---|---|
| G1 (n = 180) | G2 + G3 (n = 450) | |||
| Number (%) | Number (%) | |||
| RAD51 G135C | ||||
| G/G | 29 (16) | 100 (22) | 1.00 Ref | |
| G/C | 35 (20) | 100 (22) | 1.21 (0.68–2.12) | 0.610 |
| C/C | 116 (64) | 250 (56) | 1.60 (1.00–2.55) | 0.062 |
| G | 93 (26) | 300 (33) | 1.00 Ref | |
| C | 267 (74) | 600 (67) | 1.43 (1.09–1.88) | 0.011 |
| RAD51 G172T | ||||
| G/G | 20 (11) | 139 (31) | 1.00 Ref | |
| G/T | 50 (28) | 226 (50) | 1.53 (0.87–2.69) | 0.168 |
| T/T | 110 (61) | 85 (19) | 8.99 (5.20–15.55) | <0.0001 |
| G | 90 (25) | 504 (56) | 1.00 Ref | |
| T | 270 (75) | 396 (44) | 3.81 (2.90–5.01) | <0.0001 |
Data in boldface are statistically significant
n = 630
aAccording to FIGO criteria
bCrude odds ratio (OR); 95 % CI, confidence interval at 95 %
cChi-square