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. Author manuscript; available in PMC: 2015 Feb 14.
Published in final edited form as: Circ Res. 2013 Dec 17;114(4):616–625. doi: 10.1161/CIRCRESAHA.114.302157

Figure 3. Role of IL-17a in aortic stiffening.

Figure 3

IL-17a deficient mice were infused with chronic angiotensin II (490ng/kg/min) for 14 days. A and B, the thoracic aortas were fix-perfused for Masson’s trichrome staining and quantified for adventitia collagen staining. Scale bar indicates 100 μm. C, segments of the thoracic aorta were digested in 6N HCl at 105 °C for 48 hours and measured for hydroxyproline concentration. Data analyzed using two-way ANOVA. D and E, compliance curves and stress-strain curves for IL-17a−/− mice. Ang II, angiotensin II. Data analyzed using one-way ANOVA with repeated measures, n=6–8.