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. Author manuscript; available in PMC: 2015 Feb 14.
Published in final edited form as: Circ Res. 2013 Dec 17;114(4):616–625. doi: 10.1161/CIRCRESAHA.114.302157

Figure 4. Antihypertensive treatment (antiHBP) prevents collagen deposition, aortic stiffening and T cell infiltration.

Figure 4

Mice were treated with hydralazine and hydrochlorothiazide (320 mg/L and 60 mg/L in the drinking water) concurrently with angiotensin II infusion. Hyd, Hydralazine, HCTZ, hydrochlorothiazide. A and B, telemetry recording of blood pressures. D, day; N, night. The effects of blood pressure normalization on collagen depostion (C–E), aortic stiffening (F and G) and aorfic inflammatory cell infiltration (H–L) are shown. Scale bar indicates 100 μm. Ang II, angiotensin II. Data for blood pressure and aortic stiffness were analyzed using one-way ANOVA with repeated measurements (n=8). Collagen deposition and flow cytometry were analyzed using one-way ANOVA (n=8).