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. Author manuscript; available in PMC: 2014 Oct 6.
Published in final edited form as: Science. 2014 Sep 12;345(6202):1240–1241. doi: 10.1126/science.1252966

Figure 1. An RNA roadmap to nuclear organization.

Figure 1

Cutaway of the nucleus highlighting three organizational levels: active (left) and inactive (bottom) regions, and nuclear bodies (right). Clockwise from right to left: The nucleolus is formed around actively transcribed rRNA sites; paraspeckles are formed by the Neat1 lncRNA; the Malat1 lncRNA is present within the nuclear speckle, and actively transcribed genes are repositioned close to nuclear speckles; the inactive X chromosome (Barr body) is coated by the Xist lncRNA and dynamically repositioned from the active to inactive compartments where it is localized to the periphery of the nucleus; lncRNAs can mediate gene-gene interactions across chromosomes (bottom panel inset) and within chromosomes (top panel inset).