Figure 5. Embryonic lethality of the IIA KO embryos is underway by E9.5 and is associated with significant placental growth retardation.
(A) Whole mount views of embryos at E9.5, E10.5 and E11.5. By E9.5 many IIA KO embryos show growth retardation and aberrant development. (B) Whole mount views of the corresponding placentas reveal reduced size and less vascularization. Scale bars, 1 cm.