Table 1. Genotypic and viability analysis of offspring from K5-Cre/IIAflox/+ and IIAflox/flox matings show a non-Mendelian distribution.
Genotype | Viable Newborn at P1 | Surviving Newborn | Expected Mendelian Genotypic Proportions | ObservedGenotypicProportions |
---|---|---|---|---|
K5-Cre/IIAflox/flox | 2 | 0 | 25% | ∼1% |
K5-Cre/IIAflox/+ | 46 | 46 | 25% | 32% |
+/+/IIAflox/flox | 58 | 58 | 25% | 40% |
+/+/IIAflox/+ | 38 | 38 | 25% | 26% |