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. 2014 Nov 1;31(21):1767–1775. doi: 10.1089/neu.2013.3319

FIG. 8.

FIG. 8.

Quantification of blood spinal cord barrier disruption with very high resolution ultrasound (VHRUS). (A,B,C) Correlations between VHRUS quantification and spectrophotometry assays at 90 min and 24 h post-spinal cord injury (SCI). (D,E) Axial slices of intact spinal cord obtained with VHRUS and fluorescent microscopy. (F,G,H,I) Axial and sagittal slices of injured spinal cords obtained with VHRUS and fluorescent microscopy of the Evans blue extravasation. (J) Correlation between the amounts of extravasated hemoglobin and Evans blue in the same animal. Significant statistical correlations were obtained between VHRUS quantification and spectrophotometry assays at 90 min and 24 h post-SCI. The spatial profile of Evans blue extravasation (red fluorescence) was strikingly similar to the VHRUS signal generated by the spinal cord lesion.