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Dual use of l-Arginine by iNOS and ARG1. l-Arginine enters microglia through CAT and becomes a substrate of both pro-M1 iNOS and pro-M2 ARG1. A fine tuning between these two activities participates in microglial polarization. ARG1, arginase-1; CAT, cationic amino acid transporter; iNOS, inducible isoform of nitric oxide synthase.
