Table 4.
Final Tumor Volumes and Tumor Weights on Day 70 in Mice Receiving 3×/Week sc Injections of Vehicle Solution, BBT IFN-γ, and 10, 20, and 40 kDa PEG L103C Proteins
| Group | Tumor volume (mm3)a | Tumor weight (mg)a |
|---|---|---|
| Vehicle | 1,521±318 | 827±151 |
| BBT IFN-γ | 1,525±235 | 820±131 |
| 10 kDa PEG L103C | 594±178b | 323±95b |
| 20 kDa PEG L103C | 420±133c | 237±72c |
| 40 kDa PEG L103C | 367±100c | 226±64c |
Female athymic mice were implanted in the dermis overlying the axillae with NIH:OVCAR-3 cells on day 0. Starting on day 3, mice received 3×/week sc injections of the test proteins or vehicle solution in the abdominal region. Tumor volume was measured at weekly intervals. At sacrifice on day 70, final tumor volumes and weights were measured.
Data are means±SE for 10 mice per group.
P<0.02 versus vehicle and BBT IFN-γ groups.
P<0.005 versus vehicle and BBT IFN-γ groups.