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. Author manuscript; available in PMC: 2015 Feb 1.

Published in final edited form as: J Neurochem. 2013 Oct 28;128(3):363–375. doi: 10.1111/jnc.12476

Inter-subunit crosslinking: (TM1) and cysteines in TM2 and TM3 of β2 subunit. A. GABA responses after DTT and Cu⁺⁺:Phen application [EC₅₀ GABA were used, except for , in which spontaneous crosslinking prevented measuring EC₅₀, therefore 100 μM GABA was used). *p< 0.05 versus Cys-less receptor; two-way ANOVA, and Bonferroni post-tests (n= 5–7). B. The four closest amino acids to are shown, along with the respective Cα-Cα distances, as seen from the membrane, between β2 and α1 subunits.

Inline graphic — Inter-subunit crosslinking: (TM1) and cysteines in TM2 and TM3 of β2 subunit. A. GABA responses after DTT and Cu⁺⁺:Phen application [EC₅₀ GABA were used, except for , in which spontaneous crosslinking prevented measuring EC₅₀, therefore 100 μM GABA was used). *p< 0.05 versus Cys-less receptor; two-way ANOVA, and Bonferroni post-tests (n= 5–7). B. The four closest amino acids to are shown, along with the respective Cα-Cα distances, as seen from the membrane, between β2 and α1 subunits.