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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: J Neurochem. 2013 Oct 28;128(3):363–375. doi: 10.1111/jnc.12476

Figure 8.

Figure 8

Homology model of the α1β2γ2 GABAAR, with relevant amino acids and their interaction between (A) and within (B and C) subunits. A. Three cysteine pairs [ Inline graphic, Inline graphic, and Inline graphic] showed changes in GABA-induced responses (black lines) after redox treatment. The closest cysteine pair between the α1 and β2 subunits [ Inline graphic] did not show any evidence of crosslinking (dotted line, in red). B and C (same TMs from two different viewpoints). Four cysteine pairs within the β2 subunit [ Inline graphic, Inline graphic, Inline graphic, and Inline graphic] showed changes in GABA-induced responses (black lines) after redox treatment, indicative of crosslinking. Three additional pairs [ Inline graphic, Inline graphic, and Inline graphic] showed changes in the butanol potentiation (grey lines) after redox treatment, indicative of “silent crosslinking”: GABA responses were not affected, but the effect of the drug binding at the pocket where the disulfide bridge occurs is modified.