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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: J Neurochem. 2013 Oct 28;128(3):363–375. doi: 10.1111/jnc.12476

Table 2.

Changes observed in GABA-induced responses and butanol modulation of GABA-induced responses in selected single cysteine GABAAR mutants after butyl methanethiosulfonate (BMTS) labeling. The color indicates the color of the amino acid in the model representations.

GABAA receptor GABA responses1 Butanol effect2
BMTS BMTS + GABA
α1β2γ2 Cys-less (control) No change No change No change/ Small decrease
graphic file with name nihms532833t12.jpg Decrease NT3 No change
graphic file with name nihms532833t13.jpg No change Increase No change
graphic file with name nihms532833t14.jpg No net change No net change NT
graphic file with name nihms532833t15.jpg Increase NT Decrease
graphic file with name nihms532833t16.jpg Increase NT No change
graphic file with name nihms532833t17.jpg No net change Increase Decrease
graphic file with name nihms532833t18.jpg No change No change NT
graphic file with name nihms532833t19.jpg Decrease NT Increase4
1

EC10GABA

2

Butanol modulation of EC10 GABA

3

Not tested

4

Also changes in the flunitrazepam effect