Table 1. Clinical characteristics in 307 cases of febrile neutropenia.
Age, mean years ± SD | 40.7±14.2 |
Female sex | 148 (48.2) |
Type of cancer | |
Acute myeloid leukemia | 149 (48.5) |
Acute lymphoblastic leukemia | 45 (14.6) |
Chronic myeloid leukemia | 18 (5.8) |
Multiple myeloma | 30 (9.7) |
Lymphoma | 51 (16.6) |
Other solid tumors | 14 (4.5) |
Relapsing underlying disease | 155 (50.4) |
Clinical comorbidity | 76 (24.7) |
Phase of chemotherapy | |
Induction | 76 (24.7) |
Consolidation | 86 (28.0) |
Maintenance | 57 (18.6) |
HSCT | 88 (28.7) |
ANC at the time of diagnosis of FN, median cells/mm3 (IQR) | 130 (260) |
Duration of neutropenia, median days (IQR) | 9 (12) |
Nosocomial-acquired episodes of FN | 250 (81.7) |
Bloodstream infection | 115 (37.4) |
BSI involving Gram-positive bacteria | 46 (14.9) |
BSI involving Gram-negative bacteria | 74 (24.1) |
Polymicrobial BSI | 12 (3.9) |
BSI involving Gram-positive MDR bacteria | 27 (8.7) |
BSI involving Gram-negative MDR bacteria | 12 (3.9) |
Proven or probable IFI | 22 (7.1) |
Data presented as n (%) unless otherwise indicated. SD = standard deviation; HSCT = hematopoietic stem cell transplantation; ANC = absolute neutrophil count; FN = febrile neutropenia; IQR = interquartile range (P75–P25); BSI = bloodstream infection; MDR = multi-drug-resistant; IFI = invasive fungal infection.