Figure 4. Tumor thickness does not account for the increased signal intensity noted in the intestinal cancers.

Necropsy was performed 96 hours post injection of mice with 50 µg of CLR1502 per mouse. To examine the effect of tissue thickness, sections of normal appearing colon were layered upon each other. The radiant efficiency was measured to compare signal intensity between one, two, and three layers of normal colon and intestinal tumors. Note that one layer of normal colon is approximately 1 mm thick. Tissue thickness might account for the increased intensity seen in the adenomas, but does not account for the differences seen with the adenocarcinomas.