Table 1.

Selected genes, functions and associated disorders.

#SNPsa	Gene	Full Gene Name	Chr.	Reported Processes and Functionc	Reported Associated Disordersd
8b	FLG	filaggrin	1q21.3	Keratinocyte differentiation, multicellular organismal development, cytoplasmic membrane bounded vesicle, intermediate filament, structural molecule activity	atopic dermatitis, eczema, ichthyosis vulgaris, asthma, rheumatoid arthritis, psoriasis, skin diseases, ichythyosis, atopy, inflammation
13	SPINK 5	Serine protease inhibitor Kazal-type 5	5q32	Peptidase inhibitor activity, serine-type endopeptidase inhibitor activity	Netherton syndrome, atopic dermatitis, asthma, skin diseases, congenital ichthyosis, atopy, congenital erythroderma ichthyosiform, ichthyosis, psoriasis, growth retardation
8	TSLP	Thymic stromal lymphopoietin	5q22.1	Extracellular region and space, cytokine activity, protein binding	inflammation, asthma, atopic dermatitis, necrosis, tumors, allergic asthma, skin lesions, mixed cryoglobulinemia, allergy, membranoproliferative glomerulonephritis

^aIndicates the total number of tagging SNPs that entered the analyses.

^bThis includes the 2282del4 deletion and R501X truncation.

^cObtained from Gene Ontology website (www.geneontology.org).

^dReported disease associations were obtained from the top 10 Novoseek disease relationships hits (number of articles in which both the gene's symbol or description and the disease appear) from GeneCards® (www.genecards.org).