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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: J Allergy Clin Immunol. 2014 May 13;134(4):891–899.e3. doi: 10.1016/j.jaci.2014.03.037

Table 3.

SNP associations with asthma in replication cohorts.

Population CAMPa CAREa CCAAPSb replication GCPCR/CCCd replication GCPCRe replication GCPCRe
# cases/ # controls 334 trios 95 trios 57/184c 206/211 206/132 263/67
Race= white white white white white black
Gene SNP Major/ Minor Allele OR P-value OR P-value OR P-value OR P-value OR P-value OR P-value
SPINK5 rs2303064f G/A 0.82 0.26 2.00 0.046 1.34 0.35 1.22 0.36 - - 0.93 0.71
rs7725861 A/T 0.68 0.03 1.53 0.19 - - - - - - - -
rs9791022 T/C 0.45 0.004 1.55 0.26 - - - - - - - -
rs3777138 A/G 1.00 1.00 7.00 0.03 - - - - - - - -
rs3777142 A/T - - - - 2.14 0.04 - - - - - -
rs17704764 A/G - - - - 1.75 0.04 - - - - - -
rs6864920 A/G - - - - 0.62 0.04 - - - - - -
rs2287772 C/T - - - - 0.63 0.049 - - - - - -
rs9325073 G/C - - - - - - 1.53 0.003 - - - -
rs7445392f T/C - - - - - - - - - - 0.98 0.92
rs2303063f G/A - - - - - - - - - - 1.07 0.76
rs6892205f A/G - - - - - - - - - - 1.23 0.27
TSLP rs11466750f G/A - - - - 1.18 0.65 - - 0.98 0.93 0.85 0.47
rs11466749f T/C 0.92 0.59 0.48 0.02 1.47 0.24 - - 0.98 0.94 0.82 0.55
rs11466744 G/T 0.00 0.03 - - - - - - - - - -
rs2289276f C/T - - - - 1.08 0.77 - - 1.36 0.10 0.64 0.08
rs3806933f C/T - - - - 1.13 0.57 - - 1.24 0.21 0.64 0.04
a

The Childhood Asthma Management Program (CAMP) and Childhood Research and Education (CARE) are clinical trials included in the SNP Health Association Resource (SHARe) Asthma Resource project (SHARP) and were used as replication cohorts in this analysis. Whole genome genotyping data from the Affymetrix 6.0 chip was available on 334 CAMP and 95 CARE family trios of asthmatic children. Transmission disequilibrium tests were used for SNP associations.

b

The Cincinnati Childhood Allergy and Air Pollution (CCAAPS) birth cohort included 57 white asthmatics and 184 white non-asthmatic, SPT negative control children.

c

For TSLP analysis, controls were 141 non-asthmatic SPT positive children. Asthma was diagnosed at age 7 using pulmonary function and methacholine challenge testing.

d

New GCPCR cases were asthmatic individuals that were recruited into the GCPCR after the discovery cohort and genotyped on a separate custom Illumina chip. The CCC consisted of white adults with no history of asthma. A logistic model was fitted adjusted for sex.

e

New GCPCR controls were recruited after the discovery cohort and were non-asthmatic children with allergic rhinitis (both with and without atopic dermatitis). Shading indicates replication defined by same SNP, phenotype and direction of effect. Bolding indicates gene-level replication at p<0.05.

f

Indicates SNP was included on discovery array.