Table 1. Variables used in the model.

Test Characteristics assuming lesion ≤2 cm
Variable	Value	Range	Source
PET sensitivity	0.87	0.80 - 0.96	⁹
PET specificity	0.76	0.40 - 1.00	⁹
Nav Bronch. % diagnostic	0.61	0.54 - 0.68	^8,12
Nav Bronch sensitivity	0.98
Nav Bronch specificity	1.00	0.85 - 1.00
CT-FNA % Diagnostic	0.77	0.40 - 0.90	^12,23
CT-FNA sensitivity	0.92	0.85 - 1.00
CT-FNA specificity	1.00
Surgical Biopsy sensitivity	1.00		Reference
Surgical Biopsy specificity	1.00		Reference

QALYs and 5 Year Survival Rates
	QALYs	5 year survival	Prevalence in base case	Reference
Benign		92%¹⁸	35%	Base Case
Stage 1	13.14	68%¹¹	49%	²⁴
Stage 2	6.06	44%¹¹	11%	²⁴
Stage 3/4	3.2	21%¹¹	5%	²⁴

Complications by Intervention and Type
	CT-FNA	NB
Complication
Pneumothorax needing observation	8.4%²⁵	1.5%⁸
Pneumothorax needing chest tube	6.6%²⁵	0.6%⁸
Hemorrhage	1%²⁵	0%⁸
	Lobectomy	Wedge
Mortality	2.2%¹⁷	1.2%¹⁶
Major Morbidity	6.4%¹⁷	4.6%²²