Fig 1.
TNFα and IL-17 synergistically induce IL-13Rα2. Primary NLF (A, B) were incubated with specified cytokines for 72 hr. Kinetics of IL13RA2 expression in NLF, assayed at 24, 48 or 72 hr post stimulation (C) and decay post-cytokine withdrawal (D). Flow cytometric measurement of IL-13Rα1 and IL-13Rα2 on ALF surface post cytokine stimulation (E, F). Expression of Il13ra1 and Il13ra2 transcripts in mouse lungs following TNFα and IL-17 administration (G).