. Author manuscript; available in PMC: 2015 Oct 1.

Published in final edited form as: J Allergy Clin Immunol. 2014 Aug 28;134(4):876–882.e4. doi: 10.1016/j.jaci.2014.07.033

Table 2.

Significant results from indirect pathway analysis

FLG status	1 & 2 years	4 years	10 years	18 years	OR^a (95% CI)	P value
FLG LOF →	Eczema → Food allergy^b				2.81 (1.15, 6.86)	0.02
FLG LOF →	Eczema →	Food allergy^b			15.48 (1.32, >100)	0.02
FLG LOF →	Eczema →	Food sensitization^b			2.18 (0.99, 4.76)	0.05
FLG LOF →	Eczema →	Food allergy →	Food allergy^b		10.0 (1.14, 87.0)	0.03
FLG LOF →	→	Eczema →	Food sensitization^b		4.49 (1.44, 13.99)	0.01
FLG LOF →	→	Eczema →	→	Food sensitization^b	2.38 (1.19, 4.74)	0.01
FLG LOF →	→	Eczema →	Food sensitization →	Food allergy^b	21.9 (1.50, >100.0)	0.02

Only significant indirect paths are shown. Other models of the relationship between FLG-LOF mutations, eczema, food sensitization and food allergy were tested but did not have significant outcome.

OR represents the indirect association of FLG LOF on food allergy and food sensitization at different ages.

The outcomes of the indirect paths are in bold.