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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: J Allergy Clin Immunol. 2014 Aug 15;134(4):781–791.e1. doi: 10.1016/j.jaci.2014.05.048

Fig. 3. Multiple Downstream Consequences of Filaggrin Deficiency in Atopic Dermatitis.

Fig. 3

*Trans-urocanic acid (t-UCA) is the most potent endogenous UV-B filter in lightly-pigmented skin. Loss of t-UCA could account for the higher incidence of non-melanoma skin cancers in AD 45. (Modified from Elias & Williams, JID, 2013)