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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: J Allergy Clin Immunol. 2014 Aug 15;134(4):781–791.e1. doi: 10.1016/j.jaci.2014.05.048

Fig. 4. Abnormalities That Lead to Paracellular Barrier Abnormality in FLG-Deficient Epidermis.

Fig. 4

Lanthanum perfusion in double-allele ichthyosis vulgaris (IV) (B) vs. wild-type (A) human epidermis. C: Retraction of cytoskeleton (asterisks) in double-allele IV. D (+ inserts): Impaired loading and secretion of lamellar body cargo in double-allele IV. F–G: Post-secretory abnormalities in lamellar bilayer organization and maturation in double-allele IV (arrows). E: Normal (wild- type) human epidermis. RuO4 post-fixation (Modified from 25).