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. Author manuscript; available in PMC: 2014 Oct 16.
Published in final edited form as: Cancer Metastasis Rev. 2014 Mar;33(1):231–269. doi: 10.1007/s10555-014-9498-0

Fig. 6.

Fig. 6

Trousseau’s syndrome is characterized by a hypercoagulable state. The production of IL6 by tumors stimulates the production of thrombopoietin by the liver. Thrombopoietin (THPO), in turn, stimulates thrombocytosis. The production of PGE2 by tumors also heightens the responsiveness of platelets. Platelet-activating and thrombin-stimulating factors produced by tumors also elevate the potential for thrombosis. The combination of increased numbers of circulating platelets along with circulating prothrombogenic factors creates the hypercoagulable state first described by Trousseau