Table 4.
Environmental exposures in patients and controls stratified on HLA-DRB1*15:01 carrier status
| HLA-DRB1*15:01 + (n MS = 186/n C = 263) | HLA-DRB1*15:01 - (n MS = 133/n C = 645) | HLA-DRB1*15:01 + (n MS = 186/n C = 263) | HLA-DRB1*15:01 - (n MS = 133/n C = 645) | |
|---|---|---|---|---|
| Unadjusted analysis a p-value, OR (95% CI) | Unadjusted analysis a p-value, OR (95% CI) | Adjusted analysis b p-value, OR (95% CI) | Adjusted analysis b p-value, OR (95% CI) | |
| Smoking status* | 4.0×10−6, 2.76 (1.79-4.24) | 1.1×10−5, 2.62 (1.71-4.02) | 2.02×10−4, 2.67 (1.59-4.48) | 0.008, 2.01 (1.20-3.34) |
| Snuff use | 0.006, 0.41 (0.22-0.77) | 0.065, 0.55 (0.29-1.04) | 0.20, 0.60 (0.27-1.32) | 0.76, 0.88 (0.39-2.0) |
| Infectious mononucleosis** | 0.25, 1.46 (0.77-2.77) | 0.36, 1.29 (0.75-2.23) | 0.033, 2.22 (1.07-4.61) | 0.18, 1.55 (0.82-2.95) |
| Cat in the household before age 18 | 8.0×10−5, 0.46 (0.31-0.68) | 0.062, 0.69 (0.47-1.02) | 1.83×10−4, 0.41 (0.25-0.65) | 0.26, 0.76 (0.48-1.22) |
| Dog in the household before age 18 | 0.013, 0.61 (0.42-0.90) | 0.28, 0.81 (0.56-1.19) | 0.052, 0.63 (0.39-1.01) | 0.43, 0.83 (0.52-1.32) |
Abbreviations: SD = Standard deviation, OR = Odds ratio, CI = Confidence interval, nC = ncontrols.
aLogistic regression, unadjusted.
bLogistic regression, adjusted for age, gender, smoking status and mononucleosis.
*Not adjusted for smoking status.
**Not adjusted for mononucleosis.