Fig. 1.

Immunohistochemical localization of megalin in mouse (normal (WT) (a, c)/megalin-deficient (KO) (b, d)). Megalin is shown in green and cell nuclei in red. Non-pigmented ciliary body and retinal pigmented epithelial cells are indicated with white stars. Megalin exhibits vesicular staining in the retinal pigment epithelium cells (a) and predominantly apical vesicular staining in the non-pigmented epithelium cells of the ciliary body (c). ONL outer nuclear layer, R & D rods and cones layer, RPE retinal pigment epithelium, Ch choroid, CB ciliary body. Scale bars 10 µm