Fig. 3.

Difference in overall eye size in normal (WT) and megalin-deficient mice (KO). a Enucleated eyes from normal and megalin-deficient eyes. A large overall size difference can be observed between the normal eyes (CTRL) and the megalin-deficient (KO) eyes. b Histological cross-sections of normal (WT, left) and megalin-deficient (KO, right) mouse eyes. Scale bars 2000 µm. c Graph showing the axial length of eyes from normal (WT) and megalin-deficient (KO) mice. Bars represent median values. A large overall size difference can be observed between the normal and the megalin-deficient eyes. The axial length of the megalin-deficient eye is dramatically increased corresponding to a severe myopic refractive error in the megalin-deficient mouse eye