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. 2014 Aug 18;35(10):1247–1256. doi: 10.1038/aps.2014.63

Figure 5.

Figure 5

Cur inhibited Ang II-induced expression of CTGF, PAI-1, Col III, and FN in CFs. The cells were pretreated with Cur (5, 10, and 20 μmol/L) with or without GW9662 (5 μmol/L) for 1 h, and then subsequently stimulated with Ang II (0.1 μmol/L) for 24 h. Western blotting was used to measure the protein expression of CTGF (A), PAI-1 (A), Col III (B) and FN (B). Some cells were pretreated with Cur (5, 10, and 20 μmol/L), with or without GW9662 (5 μmol/L), for 1 h, and subsequently stimulated with Ang II (0.1 μmol/L) for 9 h. The mRNA expression of CTGF (C), PAI-1 (C), Col III (D), and FN (D) was analyzed by real-time PCR. Data are presented as the mean±SEM of three independent experiments. cP<0.01 vs control. eP<0.05, fP<0.01 vs Ang II. iP<0.01 vs Ang II+Cur 20 μmol/L.