Table 1. Laboratory data of mice treated with 24 weeks. Mean±SEM (n=10 per group). bP<0.05 vs LFD group. eP<0.05 vs HFD group.
Variables | LFD | HFD | 100ALA+HFD | 200ALA+HFD | 300Met+HFD |
---|---|---|---|---|---|
Primary body weight (g) | 23.18±0.23 | 23.87±0.29 | 23.81±0.23 | 23.40±0.29 | 23.43±0.30 |
Final body weight (g) | 31.00±0.46 | 50.05±1.01b | 41.25±1.63e | 37.50±1.43e | 35.00±0.53e |
Liver weight (g) | 1.06±0.04 | 1.91±0.18b | 1.42±0.21e | 1.25±0.05e | 1.33±0.05e |
BMI (g/cm2) | 0.32±0.07 | 0.58±0.10b | 0.41±0.13e | 0.37±0.09e | 0.39±0.11e |
Abdominal circumference (cm) | 7.63±0.13 | 9.83±0.08b | 8.43±0.37 | 7.98±0.14e | 7.50±0.14e |
Water intake (mL/d) | 6.97±0.16 | 7.87±0.17b | 6.87±0.19 | 6.26±0.05e | 6.52±0.14e |
LFD, low-fat diet, negative control group; HFD, high fat diet; 100ALA+HFD, high fat diet plus (100 mg/kg) alpha-lipoic acid; 200ALA+HFD, high fat diet plus (200 mg/kg) alpha-lipoic acid; 300Met+HFD, high fat diet plus (300 mg/kg) metformin, positive control group.