Table 3. Inhibitory effects of multi-daily gavage of S115 on Colon26 or B16 tumor growth in the allografted BALB/c mouse or B16-C57BL/6 mouse model. Average tumor weights were quantified for tumors excised from allografted models on d 10 after 7 d of treatment with increasing doses of S115. cP<0.01 vs saline.
| Group | Colon26-BALB/c mouse model |
B16-C57BL/6 mouse model |
||
|---|---|---|---|---|
| Tumor weight (g) | % Inibition | Tumor weight (g) | % Inibition | |
| Saline (20 mL/kg) | 3.69±0.31 | 3.81±0.22 | ||
| S115 (2 mg/kg) | 2.14±0.11c | 42.0 | 2.13±0.09c | 44.0 |
| S115 (8 mg/kg) | 1.31±0.14c | 64.6 | 1.30±0.07c | 65.8 |
| S115 (32 mg/kg) | 0.78±0.20c | 79.0 | 0.70±0.15c | 81.8 |