Figure 9.

Inhibition of p38 activity decreased the cytotoxicity effect of telekin. (A) Effect of NAC and SB203580 on protein expression. As shown, treatment of HepG2 cells with NAC (5 mmol/L) and SB203580 (5 μmol/L) for 24 h did not change the expression levels of p38, phospho-p38, phospho-MAPKAPK-2, Cdc25A, or Cdc2. The corresponding histograms quantified by densitometry are expressed on the right side. (B) HepG2 cells were treated with various concentrations of telekin and 0-5 μmol/L SB203580, respectively for 24 h (A) and 48 h (B). Data were obtained from triplicate experiments. ^bP<0.05, ^cP<0.01 vs 0 μmol/L SB203580 group.