Table 1. Effects of liguzinediol on hemodynamic parameters and cardiac function in Dox-treated rats in vivo. Data are expressed as mean±SEM. n=8 in each group. cP<0.01 vs control. eP<0.05, fP<0.01 vs DOX.
Control | Dox | L 5 mg/kg | L 10 mg/kg | L 20 mg/kg | Dig 0.0225 mg/kg | |
---|---|---|---|---|---|---|
SBP (mmHg) | 99.84±15.92 | 73.07±17.55c | 77.8±7.10 | 95.04±13.01e | 90.37±13.28e | 82.42±18.75 |
DBP (mmHg) | 58.11±19.22 | 51.85±17.97 | 56.09±8.87 | 75.36±13.04f | 73.74±11.16e | 62.18±20.38 |
HR (beat/min) | 348.75±50.98 | 313.88±99.74c | 369.88±36.98 | 379.00±69.88 | 403.50±23.09e | 369.63±54.99 |
+LV dp/dtmax (mmHg/s) | 7158.67±1787.06 | 3256.35±1594.88c | 5004.56±1874.28 | 5693.05±558.32f | 6502.72±1182.04f | 6270.55±937.01f |
−LV dp/dtmax (mmHg/s) | 5731.81±1541.35 | 2956.25±1396.04c | 4212.46±797.81b | 4845.39±764.72f | 5548.26±1289.85f | 4984.65±1060.00f |
LVSP | 126.71±14.79 | 80.54±11.51c | 99.00±8.91c | 110.47±16.25f | 122.80±7.92f | 117.44±14.66f |
SBP, systolic blood pressure; DBP, diastolic blood pressure; HR, heart rate; LVSP, left ventricular systolic pressure; ±LV dp/dtmax, the maximal rates of increase and decrease of left-ventricle pressure development.