Skip to main content
. 2014 Sep 15;35(10):1257–1264. doi: 10.1038/aps.2014.75

Table 1. Effects of liguzinediol on hemodynamic parameters and cardiac function in Dox-treated rats in vivo. Data are expressed as mean±SEM. n=8 in each group. cP<0.01 vs control. eP<0.05, fP<0.01 vs DOX.

  Control Dox L 5 mg/kg L 10 mg/kg L 20 mg/kg Dig 0.0225 mg/kg
SBP (mmHg) 99.84±15.92 73.07±17.55c 77.8±7.10 95.04±13.01e 90.37±13.28e 82.42±18.75
DBP (mmHg) 58.11±19.22 51.85±17.97 56.09±8.87 75.36±13.04f 73.74±11.16e 62.18±20.38
HR (beat/min) 348.75±50.98 313.88±99.74c 369.88±36.98 379.00±69.88 403.50±23.09e 369.63±54.99
+LV dp/dtmax (mmHg/s) 7158.67±1787.06 3256.35±1594.88c 5004.56±1874.28 5693.05±558.32f 6502.72±1182.04f 6270.55±937.01f
−LV dp/dtmax (mmHg/s) 5731.81±1541.35 2956.25±1396.04c 4212.46±797.81b 4845.39±764.72f 5548.26±1289.85f 4984.65±1060.00f
LVSP 126.71±14.79 80.54±11.51c 99.00±8.91c 110.47±16.25f 122.80±7.92f 117.44±14.66f

SBP, systolic blood pressure; DBP, diastolic blood pressure; HR, heart rate; LVSP, left ventricular systolic pressure; ±LV dp/dtmax, the maximal rates of increase and decrease of left-ventricle pressure development.