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. 2014 Sep 5;6(5):1759091414548916. doi: 10.1177/1759091414548916

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© The Author(s) 2014

This article is distributed under the terms of the Creative Commons Attribution 3.0 License (http://www.creativecommons.org/licenses/by/3.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (http://www.uk.sagepub.com/aboutus/openaccess.htm).

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Figure 1. — Differential expression analysis in primary Schwann cell cultures of MAL-overexpressing and wild-type mice. (a, b) Schwann cells derived from P1 mice were cultured in the presence or absence of 20 µM forskolin for 24 h and analyzed by qRT-PCR. (a) A substantial induction of Mpz expression was investigated for wild-type and MAL-overexpressing cells upon treatment; however, the expression of Mpz was significantly reduced in MAL-overexpressing Schwann cells compared with wild-type cells. (b) Under both conditions, p75^NTR mRNA level was reduced in MAL-overexpressing mice. Upon treatment, p75^NTR expression was decreased in both genotypes. Data were normalized to the expression of 60s, and values for unstimulated wild-type samples were set to 1. Data represent the mean of at least 20 independent experiments for unstimulated condition and at least 9 independent experiments for stimulated condition. The error bars indicate the SEM. (c) Gene transcripts implicated in Schwann cell development and differentiation were investigated in untreated Schwann cells by qRT-PCR. Data were normalized to the expression of 60s, and wild-type values were set to 1. The columns show the mean value of at least nine independent experiments, and the error bars indicate the SEM. *p < 0.0001. #p < 0.01.