Table 1.
Mean weights of mice during treatment period (6 weeks).
| Treatment | Weight of mice during treatment |
||||||
|---|---|---|---|---|---|---|---|
| T = 0 | Week 1 | Week 2 | Week 3 | Week 4 | Week 5 | Week 6 | |
| Veh | 23.5 ± 1.2 | 23.56 ± 1.4 | 24.4 ± 1.3 | 24.7 ± 1.7 | 25.3 ± 1.5 | 26.7 ± 1.3 | 25.8 ± 2.9 |
| Rapa | 23.4 ± 1.5 | 23.66 ± 1.5 | 24.2 ± 1.4 | 24.0 ± 1.3 | 24.1 ± 1.3 | 24.4 ± 1.6* | 23.8 ± 2.0 |
| Cup | 22.8 ± 1.8 | 20.86 ± 1.4* | 21.4 ± 1.7* | 21.7 ± 1.8* | 22.6 ± 2.1* | 22.5 ± 2.4* | 23.2 ± 2.4 |
| CupR | 23.1 ± 1.9 | 21.4 ± 1.7* | 21.2 ± 1.4* | 22.1 ± 1.5* | 22.7 ± 1.4* | 22.8 ± 1.5* | 24.1 ± 1.3 |
Note. The mean weight of the mice on a regular diet and injected with vehicle (Veh, n = 25) was compared with mice injected with rapamycin (Rapa, n = 31), cuprizone plus vehicle (Cup, n = 35), and cuprizone plus rapamycin (CupR, n = 35) after each week of treatment. One week following treatment, the weight of Cup- and CupR-treated mice was significantly different than Veh and Rapa, and this difference persisted for 5 weeks of treatment. However, by the end of the treatment period (Week 6), there was no significant difference between any of the groups. With the exception of Week 5, when vehicle-injected mice had a small weight increase, the weight of the Rapa mice did not differ from Veh mice. Data are the mean ± SD analyzed by one-way ANOVA.
p < .0001, with Bonferonni’s correction for multiple comparisons.