Table 3. Differences in mean values between intervention armswith respect to the primary endpoint of the study^*.

Subgroup category	Subgroup	Adjusted difference of mean values (95% CI)	p-value
Sex	female	2.1 (1.2–3)	0.433
	no	2.45 (1.5–3.4)
Schooling (years)	<10	2.31 (1.5–3.1)	0.88
	≥ 10	2.38 (1.3–3.4)
Age (years)	≥ 75	2.80 (1.8–3.8)	0.03
	<75	1.80 (0.8–2.8)
Fear of bleeding	yes	2.75 (1.9–3.6)	0.03
	no	1.84 (1.2–2.5)

^*Covariate-adjusted difference of mean values and associated 95% confidence interval (CI) for each subgroup. The p-values are for the hypothesis of no interaction