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. 2014 Oct 6;10:2322–2331. doi: 10.3762/bjoc.10.241

Table 2.

Formation constants (Kf), solubility enhancement ratio St/S0, CE, optimum molar ratio and increase in formulation bulk of phenylpropanoids.

Guest S0
(mg/L)
CD Kf (M−1) St/S0a CE Molar ratio (PP:CD) Increase in formulation bulk

trans-Anethole (1) 22 α-CD 1274 11 0.19 1:6.38 42
β-CD 537 3 0.08 1:13.75 106
HP-β-CD 1510 14 0.22 1:5.54 56
RAMEB 2157 17 0.31 1:4.18 38
CRYSMEB 1782 15 0.26 1:4.84 40

Estragole (2) 48 α-CD 682 4 0.22 1:5.54 36
β-CD 882 3 0.28 1:4.51 35
HP-β-CD 1412 11 0.46 1:3.19 32
RAMEB 1694 12 0.55 1:2.83 26
CRYSMEB 1512 10 0.49 1:3.05 25

Isoeugenol (3) 665 α-CD 110 2 0.45 1:3.24 19
β-CD 210 1.5 0.85 1:2.18 15
HP-β-CD 449 2.7 1.82 1:1.55 14
RAMEB 428 2.6 1.73 1:1.58 13
CRYSMEB 312 2.5 1.26 1:1.79 13

Eugenol (4) 1038 α-CD 246 2 1.56 1:1.64 10
β-CD 513 2.1 3.25 1:1.31 9
HP-β-CD 445 2.2 2.81 1:1.36 12
RAMEB 550 2.2 3.48 1:1.29 11
CRYSMEB 440 2.1 2.78 1:1.36 10

p-Coumaric acid (5) 344 α-CD 1988 4.8 4.17 1:1.24 7
β-CD 306 2.8 0.64 1:2.56 18
HP-β-CD 1099 4.4 2.30 1:1.43 13
RAMEB 1228 4.4 2.57 1:1.39 11
CRYSMEB 900 4 1.89 1:1.53 11

Caffeic acid (6) 300 α-CD 1819 5.5 3.03 1:1.33 7
β-CD 425 3.5 0.71 1:2.41 15
HP-β-CD 534 3.8 0.89 1:2.12 18
RAMEB 825 4.4 1.37 1:1.73 13
CRYSMEB 552 3.8 0.92 1:2.09 14

Ferulic acid (7) 333 α-CD 1737 5.2 2.98 1:1.34 7
β-CD 326 3.1 0.56 1:2.79 16
HP-β-CD 833 4.4 1.43 1:1.70 13
RAMEB 1045 4.8 1.79 1:1.56 11
CRYSMEB 512 3.8 0.88 1:2.14 13

aSt and S0 are the guest solubility in 10 mM CD solution and in water, respectively.