Fig. 3.

Effects of chronic hypoxia on contractile protein colocalization. Interactions between smooth muscle contractile proteins assayed through confocal colocalization microscopy revealed a 704% increase in MLC₂₀-SMαA colocalization and a 335% increase in MLCK-MLC₂₀ colocalization in hypoxic compared with normoxic arteries. For MLCK-SMαA colocalization, however, coefficients were similar in both normoxic and hypoxic arteries. Immunohistochemistry images show similar patterns of change (bottom). Results are presented as means ± SE for n ≥ 5 for all experimental groups. Comparative significant differences: *P < 0.05.