Table 1.

Average arterial partial pressures of CO₂ and O₂, pH, and MAP before and 60 min after central neural apnea or an equivalent duration in time control rats receiving a similar surgery, but no neural apnea

		PaCO2	PaO2	pH	MAP
Time control	Baseline	46.2 ± 0.9	279 ± 8	7.4 ± 0.0	126 ± 4
	60 min	46.0 ± 1.0	280 ± 6	7.4 ± 0.0	111 ± 5
HSD + vehicle	Baseline	47.5 ± 0.8	277 ± 9	7.4 ± 0.0	129 ± 5
Neural apnea	60 min	47.3 ± 0.7	270 ± 8	7.4 ± 0.0	122 ± 7
CRSD + vehicle	Baseline	46.8 ± 1.8	274 ± 6	7.4 ± 0.0	107 ± 7*†
Neural apnea	60 min	46.9 ± 1.8	264 ± 5	7.4 ± 0.0	101 ± 8†
HSD + APV	Baseline	46.4 ± 1.5	248 ± 9	7.3 ± 0.0	129 ± 5
Neural apnea	60 min	46.3 ± 1.3	251 ± 9	7.4 ± 0.0	125 ± 6
CRSD + APV	Baseline	48.3 ± 1.4	264 ± 4	7.4 ± 0.0	114 ± 6
Neural apnea	60 min	48.2 ± 1.4	259 ± 6	7.4 ± 0.0	102 ± 5§
CRSD + APV-post	Baseline	46.3 ± 1.0	258 ± 5	7.4 ± 0.0	116 ± 7
Neural apnea	60 min	46.4 ± 0.8	253 ± 4	7.4 ± 0.0	100 ± 7
CRSD + sTNFR1 and APV-post	Baseline	51.1 ± 1.1*‡	264 ± 15	7.3 ± 0.0	107 ± 11*
Neural apnea	60 min	51.5 ± 1.2*‡	249 ± 17	7.3 ± 0.0*‡	95 ± 10
CRSD + APV-post and PKCζ-PS	Baseline	48.6 ± 1.1	266 ± 6	7.3 ± 0.0	113 ± 7
Neural apnea	60 min	48.2 ± 1.3	264 ± 3	7.3 ± 0.0	89 ± 4*
CRSD + APV-post and scrPKCζ-PS	Baseline	48.0 ± 1.1	265 ± 10	7.3 ± 0.0	120 ± 7
Neural apnea	60 min	48.8 ± 1.1	259 ± 11	7.3 ± 0.0*	101 ± 9

APV, DL-2-amino-5-phosphonopentanoic acid; APV-post, APV administered 4 min before the end of neural apnea; CRSD, Charles River Sprague-Dawley rats; HSD, Harlan Sprague-Dawley rats; MAP, mean arterial blood pressure; Pa_O2, arterial partial pressure of O₂, Pa_CO2, arterial partial pressure of CO₂; PKCζ-PS, myristoylated ζ-pseudosubstrate inhibitory peptide; scrPKCζ-PS, myristoylated scrambled ζ-pseudosubstrate peptide; sTNFR1, soluble tumor necrosis factor-α receptor. Values are means ± SE

^*Significantly different than time controls (P < 0.05);

^†significantly different than HSD + vehicle;

^‡significantly different than CRSD + APV-post;

^§significantly different than HSD + APV.