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PDGFR-α knockdown differentially regulates gene transcription of TβRI and TβRII. A: real-time RT-PCR was performed with RNA of control or PDGFR-α knockdown HSCs. Knockdown of PDGFR-α but not PDGFR-β significantly increased transcription of endogenous TβRII compared with control HSCs. *P < 0.05 by ANOVA, n = 3 repeats. B: knockdown of either PDGFR-α or PDGFR-β significantly reduced endogenous TβRI mRNA levels compared with control HSCs. *P < 0.05 by ANOVA, n = 4 repeats.
