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. 2014 Aug 7;307(7):G700–G710. doi: 10.1152/ajpgi.00163.2014

Fig. 1.

Fig. 1.

Effect of trypsin inhibitor (TI) and PD-0325901 on extracellular signal-related kinase (ERK) signaling. A: Western blot (top) and signal quantitation (bottom) of pancreatic phospho (p)-ERK levels following TI feeding. Mice were fasted overnight and refed 0.1% TI in the chow for the indicated time. Pancreatic pERK immunoperoxidase staining of mice fasted overnight (B), fasted mice administered PD-0325901 by gavage (C), TI fed for 2 h following fasting (D), or treated with both TI and PD-0325901 (E). F: mice were fasted overnight and refed TI and PD-0325901 for the indicated times. G: phosphorylated ERK expression of fed, fasted, refed, and TI-fed mice. Values are represented as fold increase of control mice. Results in A and F are means ± SE of n = 6–10 mice. *P < 0.05 and **P < 0.01.