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Effect of PD-0325901 on pancreatic DNA synthesis and mitogenesis. 5′-Bromo-2′-deoxyuridine (BrdU) immunofluorescence of control (A), PD-0325901 (B), and TI (C) for 48 h or TI and PD-0325901 (D). E: quantitated results. K-i67 immunoperoxidase staining in control (F), PD-0325901 (G), and 0.1% TI (H) for 48 h or TI and PD-0325901 (I). Results are means ± SE of n = 8–12 mice. **P < 0.01 compared with TI.
