Fig. 6.

Effect of PD-0325901 on the expression of cell-cycle proteins in the mouse pancreas. Immunohistochemistry of cyclin D1 on mice that were refed chow (A), PD-0325901 (B), or 0.1% TI (C) for 24 h or TI and PD-0325901 (D). Western blots of cyclin D1 (E), cyclin D3 (F), cyclin E (G), cyclin A (H), and proliferating cell nuclear antigen (PCNA, I). J: GAPDH was included as a control. Values are represented as fold increase of control mice. Results are means ± SE of n = 8–10 mice. *P < 0.05 and **P < 0.01.