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. 2014 Aug 7;307(7):G700–G710. doi: 10.1152/ajpgi.00163.2014

Fig. 7.

Fig. 7.

Effect of MEK inhibition on the initiation and maintenance of pancreatic adaptive growth. A: schematic diagram of experimental procedure. Mice were fasted overnight and refed 0.1% TI continuously. The pancreas was harvested at 2 and 8 days following refeeding. At 1 or 2 days a cohort of mice was also given PD-0325901 continuously in the chow, and PW/BW was measured at 8 days. B: quantitated results of PW/BW. C: schematic of experimental procedure. Mice were fasted overnight and refed 0.1% TI continuously. The pancreas was harvested at 5 and 8 days following refeeding. At 5 days, a cohort of mice was given PD-0325901 continuously in the chow, and the pancreas was harvested at 8 days. The PW/BW was measured and quantitated in D. All results shown are means ± SE of n = 6–10 mice. NS, not significant. **P < 0.01.