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Characterization of HPLC-purified cross-linked duplex 1G6S-Et-S4U2 (a) by denaturing anion exchange HPLC (b). Alkylation at the sulfur atoms within the thionucleobases is confirmed by the strong reduction of the absorption band above 300 nm in the UV spectrum of 1G6S-Et-S4U2 (c, solid) compared to the spectrum of 1G6S∙2U4S (dashed). The thermal stability of the cross-linked duplex 1G6S-Et-S4U2 (d, solid) is drastically increased compared to 1G6S∙2U4S (dashed).
