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Opening and traceless linker removal of the cross-linked duplexes 1I6S-Et-S4U2 and 1G6S-Et-S4U2 by adding DTT (a). Denaturing anion exchange HPLC chromatograms (b, c) demonstrate that the reaction products dissociate and elute at the same retention times as their parent single strands. Furthermore, the UV absorption at 332 nm is fully recovered, indicating that the thio-keto function in the nucleobases has been restored.
